Hematopoietic stem cell homeostasis

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell homeostasis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OCIAD2, KMT2A, and SMARCD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell homeostasis activity versus OCIAD2 in STOMACH (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	OCIAD2 →	+2.545	+0.197	.006	<.001	2	8
LIVER	KMT2A →	+0.718	+0.323	.002	.005	3	6
SKIN	SMARCD1 →	+0.744	+0.171	.007	.008	3	5
OVARY	TFAM →	+0.622	+0.212	<.001	.001	3	5
SKIN	ATXN2 →	+0.582	+0.211	.002	.005	3	4
KIDNEY	XAF1 →	-2.649	-0.245	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061484 vs OCIAD2 — STOMACH

Explore this scatter interactively →