T follicular helper cell differentiation

Across TCGA cell cohorts, RNA activity of the T follicular helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNFT2, SMARCAL1, and MRPL2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RNFT2 grouped by T follicular helper cell differentiation-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RNFT2 →	-0.643	-0.655	.002	.005	3	4
KIDNEY	SMARCAL1 →	+0.552	+0.971	.003	.007	3	3
CNS	MRPL2 →	-0.556	-1.035	<.001	.005	3	3
CNS	DAAM2 →	+1.452	+0.900	.003	<.001	3	3
CNS	PTPRM →	+1.789	+0.803	.004	.004	3	3
LUNG_SCLC	UCKL1 →	+0.570	+1.007	.006	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RNFT2 by T follicular helper cell differentiation activity — CNS

Explore this box plot interactively →