T follicular helper cell differentiation

Across TCGA cell cohorts, RNA activity of the T follicular helper cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CABP7, NFKBIA, and TAZ, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, T follicular helper cell differentiation activity versus CABP7 in BLOOD_Lymphoma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP7 →	+0.081	+0.394	.002	<.001	3	2
BLOOD_Lymphoma	NFKBIA →	+2.276	+0.329	<.001	.005	3	2
BLOOD_Lymphoma	TAZ →	+0.780	+0.347	.006	.004	3	2
BLOOD_Lymphoma	TMEM214 →	+0.716	+0.256	.001	.006	3	2
BREAST	PLD2 →	+1.823	+0.362	<.001	.009	3	2
BLOOD_Lymphoma	NXNL2 →	+0.062	+0.304	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061470 vs CABP7 — BLOOD_Lymphoma

Explore this scatter interactively →