Protein localization to lysosome

Across TCGA patient cohorts, RNA activity of the Protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the KIRP cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNRC6B, NFAT5, and MED13, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to lysosome activity versus TNRC6B in KIRP (Pearson r = 0.60).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIRP	TNRC6B →	+0.859	+0.047	<.001	<.001	3	34
THYM	NFAT5 →	+2.384	+0.073	<.001	<.001	3	34
UVM	MED13 →	+1.146	+0.036	<.001	<.001	3	34
THYM	BICRAL →	+1.244	+0.072	<.001	<.001	3	34
UVM	PPWD1 →	+1.352	+0.035	<.001	<.001	3	34
UVM	INO80D →	+1.013	+0.035	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061462 vs TNRC6B — KIRP

Explore this scatter interactively →