Protein localization to lysosome

Across TCGA cell cohorts, RNA activity of the Protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GPR107, KIAA2013, and RWDD4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GPR107 grouped by Protein localization to lysosome-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	GPR107 →	-0.521	-0.690	.007	.008	3	4
BLOOD_Leukemia	KIAA2013 →	-0.420	-0.939	.002	.005	3	3
SOFT_TISSUE	RWDD4 →	+0.531	+0.999	.004	.007	3	3
PANCREAS	RBFA →	-1.273	-0.350	.003	<.001	3	3
LARGE_INTESTINE	MGA →	-0.804	-0.192	.005	<.001	3	3
LARGE_INTESTINE	PRRC2A →	-0.567	-0.466	.007	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GPR107 by Protein localization to lysosome activity — CNS

Explore this box plot interactively →