Protein localization to lysosome

Across TCGA cell cohorts, RNA activity of the Protein localization to lysosome pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CACNG4, SLAMF1, and CBLC, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CACNG4 grouped by Protein localization to lysosome-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	CACNG4 →	+0.131	+0.085	.005	.001	3	4
KIDNEY	SLAMF1 →	+0.151	+0.063	.002	.008	3	4
OESOPHAGUS	CBLC →	+0.101	+0.085	.003	.004	2	5
OVARY	STX1B →	-0.202	-0.098	<.001	.002	3	4
LUNG_SCLC	GFOD2 →	+0.118	+0.107	.008	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MAX →	-0.372	-0.094	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CACNG4 by Protein localization to lysosome activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →