Protein localization to lysosome

Across TCGA cell cohorts, RNA activity of the Protein localization to lysosome pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCARB2, CLTC, and SNX3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to lysosome activity versus SCARB2 in BLOOD_Lymphoma (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SCARB2 →	+2.078	+0.237	.005	.002	3	6
UPPER_AERODIGESTIVE_TRACT	CLTC →	+0.871	+0.149	.003	.006	1	7
BLOOD_Leukemia	SNX3 →	+0.668	+0.163	<.001	.001	3	5
LUNG_NSCLC_LUSC	SERINC1 →	+1.224	+0.360	.004	.002	3	5
BLOOD_Leukemia	MBTPS2 →	+0.505	+0.232	.004	<.001	3	5
BLOOD_Myeloma	SMPD1 →	+1.206	+0.323	.007	.007	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061462 vs SCARB2 — BLOOD_Lymphoma

Explore this scatter interactively →