Trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Trophoblast cell migration pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GBF1, MMP9, and TPR_S379, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophoblast cell migration activity versus GBF1 in BRCA (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GBF1 →	-0.183	-0.036	<.001	<.001	3	5
GBM	MMP9 →	+1.491	+0.083	<.001	.001	3	5
LUAD	TPR_S379 →	+0.209	+0.057	.004	.006	3	4
GBM	SYNPO_S838 →	+0.796	+0.100	.001	<.001	3	4
PDAC	TIMP1 →	+0.500	+0.058	.001	.001	3	4
PDAC	ADAMTSL2 →	+0.698	+0.044	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061450 vs GBF1 — BRCA

Explore this scatter interactively →