Trophoblast cell migration

Across TCGA patient cohorts, RNA activity of the Trophoblast cell migration pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, UNC5B, and HTRA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophoblast cell migration activity versus GJA1 in HNSC (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GJA1 →	+1.447	+1.214	<.001	<.001	3	6
LSCC	UNC5B →	+0.579	+0.648	.005	.007	3	4
GBM	HTRA1 →	+0.674	+0.239	.001	.002	3	4
LSCC	SNAI2 →	+0.660	+0.722	.001	.003	3	4
HNSC	COL5A3 →	+0.802	+1.104	<.001	<.001	3	4
LSCC	JAG1 →	+0.768	+0.922	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061450 vs GJA1 — HNSC

Explore this scatter interactively →