Trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Trophoblast cell migration pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSD17B10, PFAS, and ACLY, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, HSD17B10 grouped by Trophoblast cell migration-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	HSD17B10 →	-0.231	-0.158	.006	.009	3	6
PANCREAS	PFAS →	-0.329	-0.298	.001	.001	3	5
STOMACH	ACLY →	-0.413	-0.176	.004	.007	3	5
BLOOD_Myeloma	CRK →	+0.170	+0.072	.001	.007	3	4
LIVER	ARHGEF12 →	+0.324	+0.409	<.001	<.001	3	4
LIVER	SLC46A1 →	+0.239	+0.239	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

HSD17B10 by Trophoblast cell migration activity — KIDNEY

Explore this box plot interactively →