Trophoblast cell migration

Across TCGA cell cohorts, RNA activity of the Trophoblast cell migration pathway is significantly associated with the drug response of multiple features, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are IAP_7638, LCL161, and JNK-9L, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IAP_7638 grouped by Trophoblast cell migration-low versus -high activity in CNS.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IAP_7638 →	-1.393	-0.275	.006	.026	3	1
CNS	LCL161 →	-0.853	-0.275	.029	.026	3	1
CNS	JNK-9L →	-0.333	-0.275	.044	.026	3	1
CNS	KIN001-260 →	-0.823	-0.275	.025	.026	3	1
CNS	IAP_5620 →	-1.520	-0.279	.036	.037	2	1
CNS	AICA Ribonucleotide →	-0.659	-0.275	.023	.026	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IAP_7638 by Trophoblast cell migration activity — CNS

Explore this box plot interactively →