Renal system vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Renal system vasculature morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1_T1263, COL1A1, and COL3A1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system vasculature morphogenesis activity versus TLN1_T1263 in UCEC (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TLN1_T1263 →	+0.869	+0.138	<.001	<.001	3	10
OV	COL1A1 →	+0.825	+0.148	<.001	<.001	3	10
CCRCC	COL3A1 →	+0.940	+0.099	<.001	<.001	3	10
COAD	PCOLCE →	+0.681	+0.088	<.001	<.001	3	10
OV	ASPN →	+0.890	+0.112	<.001	<.001	3	9
OV	SERPINH1 →	+0.491	+0.108	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061438 vs TLN1_T1263 — UCEC

Explore this scatter interactively →