Renal system vasculature morphogenesis

Across TCGA patient cohorts, RNA activity of the Renal system vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AAMP, TRAPPC9, and SEMA4D, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system vasculature morphogenesis activity versus AAMP in LSCC (Pearson r = -0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AAMP →	-0.290	-0.532	.009	<.001	3	4
PDAC	TRAPPC9 →	-0.296	-0.658	.003	.002	3	4
PDAC	SEMA4D →	-0.323	-0.688	.005	<.001	3	4
PDAC	PRKAR1AP1 →	-0.285	-0.637	.001	.001	3	4
BRCA	SVEP1 →	+0.901	+0.663	<.001	.007	3	4
BRCA	MRPL14 →	-0.586	-1.066	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061438 vs AAMP — LSCC

Explore this scatter interactively →