Renal system vasculature morphogenesis

Across TCGA cell cohorts, RNA activity of the Renal system vasculature morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRC1, IGF2BP2, and LONP2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRRC1 grouped by Renal system vasculature morphogenesis-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRRC1 →	-0.615	-0.725	.001	.001	3	6
LIVER	IGF2BP2 →	-0.969	-0.860	.003	.005	3	3
BLOOD_Myeloma	LONP2 →	-0.797	-1.408	.001	<.001	3	3
STOMACH	ACOT11 →	-1.843	-0.936	.009	.007	3	3
BREAST	ALDH18A1 →	-0.742	-0.760	<.001	.003	3	3
BLOOD_Myeloma	ATG2A →	-1.062	-1.704	.007	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRRC1 by Renal system vasculature morphogenesis activity — BREAST

Explore this box plot interactively →