Renal system vasculature development

Across TCGA patient cohorts, RNA activity of the Renal system vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC2A3, CCDC102B, and NRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system vasculature development activity versus SLC2A3 in OV (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SLC2A3 →	+0.618	+0.546	.006	.001	3	4
COAD	CCDC102B →	+0.476	+0.724	<.001	<.001	3	4
GBM	NRP1 →	+0.552	+0.386	.001	<.001	3	4
OV	PMP22 →	+0.703	+0.745	.005	<.001	3	3
OV	PDGFRB →	+0.767	+0.587	.009	<.001	3	3
OV	PLVAP →	+0.883	+0.516	.006	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061437 vs SLC2A3 — OV

Explore this scatter interactively →