Renal system vasculature development

Across TCGA cell cohorts, RNA activity of the Renal system vasculature development pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NNMT, MCAM, and CENPE, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal system vasculature development activity versus NNMT in LARGE_INTESTINE (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	NNMT →	+1.803	+0.432	.005	.006	3	4
LUNG_NSCLC_LUAD	MCAM →	+3.480	+0.766	<.001	.003	3	4
BLOOD_Leukemia	CENPE →	+1.194	+1.754	.003	.003	3	4
KIDNEY	TTC19 →	-0.720	-1.669	<.001	<.001	3	3
LARGE_INTESTINE	ZNF653 →	-0.617	-0.424	.007	.008	3	3
LARGE_INTESTINE	MCIDAS →	-1.316	-0.424	.001	.008	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061437 vs NNMT — LARGE_INTESTINE

Explore this scatter interactively →