Establishment of skin barrier

Across TCGA patient cohorts, RNA activity of the Establishment of skin barrier pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DGKA, LCN2, and CHAMP1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of skin barrier activity versus DGKA in HNSC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DGKA →	+0.395	+0.107	<.001	<.001	3	7
BRCA	LCN2 →	+1.058	+0.068	<.001	<.001	3	7
GBM	CHAMP1 →	-0.349	-0.054	<.001	.002	3	7
OV	SUGP2 →	-0.417	-0.066	<.001	<.001	3	6
LSCC	SUGP2_S277 →	-0.770	-0.082	<.001	<.001	3	6
BRCA	TNKS1BP1_S178 →	+0.590	+0.060	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061436 vs DGKA — HNSC

Explore this scatter interactively →