Establishment of skin barrier

Across TCGA patient cohorts, RNA activity of the Establishment of skin barrier pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AHNAK2, YPEL1, and EPHA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment of skin barrier activity versus AHNAK2 in HNSC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AHNAK2 →	+1.039	+0.682	<.001	.003	3	5
HNSC	YPEL1 →	-0.737	-1.285	<.001	<.001	3	4
PDAC	EPHA2 →	+0.517	+0.299	<.001	.003	3	4
PDAC	KLF15 →	-0.985	-0.384	<.001	.001	3	4
HNSC	ACSM1 →	-0.782	-0.889	.002	.006	3	4
LUAD	PLEC →	+0.672	+0.508	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061436 vs AHNAK2 — HNSC

Explore this scatter interactively →