Establishment of skin barrier

Across TCGA cell cohorts, RNA activity of the Establishment of skin barrier pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IKBKG, ALOX12B, and ELANE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IKBKG grouped by Establishment of skin barrier-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IKBKG →	-0.231	-1.179	.007	.002	2	6
BLOOD_Myeloma	ALOX12B →	-0.275	-1.580	<.001	<.001	3	4
CNS	ELANE →	+0.212	+1.023	<.001	.001	3	4
LUNG_NSCLC_LUSC	NSUN2 →	-0.195	-1.280	<.001	.002	3	4
BONE	FBXL6 →	-0.202	-1.767	.009	<.001	3	3
BONE	LHFPL6 →	-0.240	-1.305	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IKBKG by Establishment of skin barrier activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →