Establishment of skin barrier

Across TCGA cell cohorts, RNA activity of the Establishment of skin barrier pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMP1, SND1, and ST8SIA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LAMP1 grouped by Establishment of skin barrier-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LAMP1 →	-0.787	-1.113	<.001	<.001	3	5
LUNG_NSCLC_LUAD	SND1 →	-0.521	-0.624	.004	.007	3	3
SKIN	ST8SIA2 →	+1.280	+0.570	.001	.003	3	3
URINARY_TRACT	SLC15A3 →	-2.641	-0.399	<.001	<.001	3	3
URINARY_TRACT	EMC1 →	-1.056	-0.495	.004	.001	3	3
URINARY_TRACT	ST6GAL1 →	+1.461	+0.399	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LAMP1 by Establishment of skin barrier activity — OVARY

Explore this box plot interactively →