Heart trabecula morphogenesis

Across TCGA patient cohorts, RNA activity of the Heart trabecula morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BGN, RSU1, and COL18A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula morphogenesis activity versus BGN in OV (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	BGN →	+0.669	+0.049	.003	.003	3	9
LSCC	RSU1 →	+0.370	+0.061	<.001	<.001	3	9
OV	COL18A1 →	+0.480	+0.055	<.001	<.001	3	9
GBM	TNS2 →	+0.272	+0.051	<.001	<.001	3	8
BRCA	CAVIN2 →	+0.564	+0.039	<.001	<.001	3	8
BRCA	LUM →	+0.828	+0.034	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061384 vs BGN — OV

Explore this scatter interactively →