Heart trabecula morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart trabecula morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FKBP1A, NPM1, and SARNP, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula morphogenesis activity versus FKBP1A in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	FKBP1A →	+0.940	+0.496	<.001	.001	3	6
PANCREAS	NPM1 →	+0.759	+1.236	.003	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	SARNP →	+0.822	+1.213	.003	.004	3	5
URINARY_TRACT	ADAM8 →	-2.697	-1.550	.008	.006	2	6
PANCREAS	SAMM50 →	+0.621	+1.495	<.001	.001	3	5
PANCREAS	DTD2 →	+0.943	+1.346	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061384 vs FKBP1A — BLOOD_Lymphoma

Explore this scatter interactively →