Heart trabecula morphogenesis

Across TCGA cell cohorts, RNA activity of the Heart trabecula morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PSMA3, PSMA2, and RPS12, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Heart trabecula morphogenesis activity versus PSMA3 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.72).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	PSMA3 →	+1.259	+1.809	<.001	<.001	3	17
URINARY_TRACT	PSMA2 →	+1.343	+1.770	.004	.007	3	17
OVARY	RPS12 →	+1.783	+1.437	<.001	<.001	3	17
OESOPHAGUS	RAD23B →	+1.370	+1.157	<.001	.001	3	17
UPPER_AERODIGESTIVE_TRACT	NEDD8 →	+1.508	+1.766	<.001	<.001	3	17
URINARY_TRACT	PCNA →	+2.101	+1.795	.008	.008	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061384 vs PSMA3 — UPPER_AERODIGESTIVE_TRACT

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