Trabecula morphogenesis

Across TCGA patient cohorts, RNA activity of the Trabecula morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF423, SFRP2, and MAMDC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula morphogenesis activity versus ZNF423 in HNSC (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ZNF423 →	+0.731	+0.889	<.001	<.001	3	5
CCRCC	SFRP2 →	+1.366	+0.646	.006	.001	3	4
CCRCC	MAMDC2 →	+0.863	+0.732	<.001	<.001	3	4
COAD	OMD →	+1.168	+0.985	.004	<.001	3	4
GBM	SOCS2-AS1 →	+0.659	+0.597	.004	.009	3	4
HNSC	FNDC1 →	+1.200	+0.809	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061383 vs ZNF423 — HNSC

Explore this scatter interactively →