Trabecula morphogenesis

Across TCGA cell cohorts, RNA activity of the Trabecula morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MMACHC, SLC4A2, and G6PD, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MMACHC grouped by Trabecula morphogenesis-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MMACHC →	-0.988	-0.278	.007	<.001	3	4
BLOOD_Myeloma	SLC4A2 →	-1.384	-0.284	.005	.004	3	4
PANCREAS	G6PD →	+1.163	+0.179	.002	.009	3	4
LUNG_NSCLC_LUSC	GOLGA5 →	+0.728	+0.250	.001	.004	2	5
OVARY	CA11 →	-1.566	-0.239	.001	.005	3	4
BREAST	FBXL20 →	-1.080	-0.185	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MMACHC by Trabecula morphogenesis activity — BLOOD_Myeloma

Explore this box plot interactively →