Trabecula morphogenesis

Across TCGA cell cohorts, RNA activity of the Trabecula morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP5F1D, RTN4IP1, and CCT3, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trabecula morphogenesis activity versus ATP5F1D in STOMACH (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ATP5F1D →	+1.410	+1.659	<.001	<.001	3	6
BLOOD_Lymphoma	RTN4IP1 →	+1.172	+0.394	<.001	<.001	3	6
LUNG_NSCLC_LUSC	CCT3 →	+1.049	+1.668	.004	<.001	3	6
BLOOD_Lymphoma	NME1 →	+1.314	+0.464	<.001	<.001	3	6
STOMACH	LAMA3 →	-3.652	-1.188	.003	.006	3	6
BLOOD_Lymphoma	MPC2 →	+0.766	+0.265	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061383 vs ATP5F1D — STOMACH

Explore this scatter interactively →