Positive regulation of triglyceride lipase activity

pathway activity — cross-omics
GO:0061365Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of triglyceride lipase activity pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ICAM1, IFI30, and PSMB10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAICAM1 →+0.640+0.131<.001<.00136
BRCAIFI30 →+0.313+0.073<.001<.00136
BRCAPSMB10 →+0.553+0.103<.001<.00136
COADCD38 →+0.470+0.080.004<.00136
PDACCFI →-0.429-0.143<.001<.00135
UCECSASH3 →+0.444+0.269.001.00835
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration