Regulation of Wnt protein secretion

Across TCGA patient cohorts, RNA activity of the Regulation of Wnt protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPR2, PNOC, and CHRDL2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of Wnt protein secretion activity versus AVPR2 in HNSC (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	AVPR2 →	-0.369	-0.198	.004	<.001	3	3
HNSC	PNOC →	-0.497	-0.198	.001	<.001	3	3
HNSC	CHRDL2 →	-0.668	-0.166	.003	.001	3	3
GBM	RPL34-DT →	-0.339	-0.147	<.001	.001	3	3
LUAD	TMC3-AS1 →	-0.432	-0.551	.004	<.001	3	3
PDAC	CSDC2 →	+0.357	+0.270	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061356 vs AVPR2 — HNSC

Explore this scatter interactively →