Regulation of Wnt protein secretion

Across TCGA cell cohorts, RNA activity of the Regulation of Wnt protein secretion pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSG101, SLC39A14, and BMP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSG101 grouped by Regulation of Wnt protein secretion-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	TSG101 →	+0.430	+0.208	.001	.001	3	3
BREAST	SLC39A14 →	-1.447	-0.354	.006	.008	3	2
BREAST	BMP2 →	-1.775	-0.336	.002	.006	3	2
KIDNEY	PDCL3 →	+1.097	+0.279	.001	.008	3	2
KIDNEY	FARS2 →	+0.584	+0.196	.001	.004	3	2
KIDNEY	LRRC66 →	-0.280	-0.203	.009	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSG101 by Regulation of Wnt protein secretion activity — KIDNEY

Explore this box plot interactively →