Regulation of Wnt protein secretion

Across TCGA cell cohorts, RNA activity of the Regulation of Wnt protein secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VEGFC, RAP1A, and GPAT4, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, VEGFC grouped by Regulation of Wnt protein secretion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	VEGFC →	-0.157	-0.231	.001	.001	3	3
SKIN	RAP1A →	+0.300	+0.229	<.001	<.001	3	2
SKIN	GPAT4 →	+0.130	+0.257	.005	<.001	3	2
SKIN	MSX1 →	-0.163	-0.229	.003	<.001	3	2
SKIN	HMGB4 →	-0.236	-0.229	.001	<.001	3	2
SKIN	GPR141 →	+0.220	+0.229	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

VEGFC by Regulation of Wnt protein secretion activity — SKIN

Explore this box plot interactively →