Neural precursor cell proliferation

Across TCGA patient cohorts, RNA activity of the Neural precursor cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are THBS3, FERMT2, and SULF1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural precursor cell proliferation activity versus THBS3 in UCEC (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THBS3 →	+0.666	+0.044	<.001	<.001	3	8
BRCA	FERMT2 →	+0.639	+0.026	<.001	<.001	3	8
LSCC	SULF1 →	+0.653	+0.033	.001	<.001	3	8
LSCC	TIMP2 →	+0.622	+0.036	<.001	<.001	3	8
BRCA	DPYSL3 →	+0.727	+0.025	<.001	<.001	3	8
LSCC	ISLR →	+0.633	+0.036	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061351 vs THBS3 — UCEC

Explore this scatter interactively →