Neural precursor cell proliferation

Across TCGA cell cohorts, RNA activity of the Neural precursor cell proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MNT, TPK1, and TMEM130, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MNT grouped by Neural precursor cell proliferation-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MNT →	-0.313	-0.290	.003	.002	3	5
PANCREAS	TPK1 →	-0.135	-0.155	.008	.002	2	6
BONE	TMEM130 →	-0.240	-0.375	.006	.002	3	4
LIVER	LRRC39 →	-0.341	-0.218	.006	.004	3	4
UPPER_AERODIGESTIVE_TRACT	CBWD2 →	-0.211	-0.169	<.001	.001	3	4
LUNG_NSCLC_LUAD	PDE9A →	-0.183	-0.140	.006	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MNT by Neural precursor cell proliferation activity — BLOOD_Lymphoma

Explore this box plot interactively →