Neural precursor cell proliferation

Across TCGA cell cohorts, RNA activity of the Neural precursor cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IPO11, ANKRD31, and MATR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural precursor cell proliferation activity versus IPO11 in LARGE_INTESTINE (Pearson r = -0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IPO11 →	-0.507	-0.162	.001	.003	3	5
OESOPHAGUS	ANKRD31 →	-0.284	-0.237	<.001	.003	3	4
LARGE_INTESTINE	MATR3 →	-0.607	-0.164	<.001	.001	3	4
LARGE_INTESTINE	UTP15 →	-0.739	-0.227	.001	<.001	3	4
LARGE_INTESTINE	ASB8 →	-0.464	-0.132	<.001	.004	3	4
STOMACH	PPP1CC →	-1.091	-0.219	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061351 vs IPO11 — LARGE_INTESTINE

Explore this scatter interactively →