Establishment or maintenance of monopolar cell polarity

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of monopolar cell polarity pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CETN2, MAP1B, and MAP1B_S937, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of monopolar cell polarity activity versus CETN2 in LUAD (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CETN2 →	+0.440	+0.070	<.001	<.001	3	8
UCEC	MAP1B →	+0.741	+0.064	.001	.003	3	7
LSCC	MAP1B_S937 →	+1.349	+0.044	<.001	<.001	3	7
PDAC	CD44_S697 →	-0.722	-0.060	<.001	<.001	3	7
LSCC	ARHGEF1 →	-0.205	-0.050	<.001	<.001	3	7
HNSC	ISG20 →	-0.659	-0.059	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061339 vs CETN2 — LUAD

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