Establishment or maintenance of monopolar cell polarity

Across TCGA cell cohorts, RNA activity of the Establishment or maintenance of monopolar cell polarity pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP1R15A, ZNF823, and NLRP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PPP1R15A grouped by Establishment or maintenance of monopolar cell polarity-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PPP1R15A →	+1.728	+0.931	.001	.006	3	4
SOFT_TISSUE	ZNF823 →	-0.981	-1.346	.003	.002	3	4
STOMACH	NLRP1 →	+3.667	+1.370	<.001	.001	3	4
OESOPHAGUS	SLC25A19 →	-0.941	-1.376	.002	.009	3	3
OESOPHAGUS	EPS8 →	-1.812	-1.457	.003	.003	3	3
OESOPHAGUS	ZNF443 →	-0.891	-1.574	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PPP1R15A by Establishment or maintenance of monopolar cell polarity activity — STOMACH

Explore this box plot interactively →