Cardiac conduction

Across TCGA cell cohorts, RNA activity of the Cardiac conduction pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALS2CL, PLEKHG6, and LSR, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac conduction activity versus ALS2CL in URINARY_TRACT (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	ALS2CL →	+2.693	+0.596	.004	<.001	3	8
URINARY_TRACT	PLEKHG6 →	+3.330	+0.504	<.001	<.001	3	8
URINARY_TRACT	LSR →	+3.568	+0.531	.008	.001	3	8
URINARY_TRACT	EPHA1 →	+4.024	+0.579	<.001	<.001	3	8
LIVER	MPZL3 →	+2.540	+0.461	.001	.004	3	8
URINARY_TRACT	DLG4 →	-3.070	-0.509	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061337 vs ALS2CL — URINARY_TRACT

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