Renal tubule development

Across TCGA patient cohorts, RNA activity of the Renal tubule development pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADD3, DDX21_S89, and RNF213, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal tubule development activity versus ADD3 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ADD3 →	+0.502	+0.025	<.001	<.001	3	8
BRCA	DDX21_S89 →	-0.887	-0.023	<.001	<.001	3	8
PDAC	RNF213 →	-0.417	-0.037	<.001	<.001	3	8
BRCA	WARS1 →	-0.702	-0.031	<.001	<.001	3	8
BRCA	FERMT2 →	+0.383	+0.025	<.001	<.001	3	8
BRCA	HSPG2 →	+0.646	+0.039	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061326 vs ADD3 — BRCA

Explore this scatter interactively →