Renal tubule development

Across TCGA patient cohorts, RNA activity of the Renal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISLR, KANK2, and JAM3, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal tubule development activity versus ISLR in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ISLR →	+0.821	+0.550	<.001	<.001	3	7
BRCA	KANK2 →	+0.719	+0.554	<.001	<.001	3	7
BRCA	JAM3 →	+0.907	+1.039	<.001	<.001	3	6
BRCA	MSRB3 →	+0.792	+0.560	<.001	<.001	3	6
BRCA	MYL9 →	+0.902	+0.579	<.001	<.001	3	6
LSCC	BOC →	+0.948	+0.380	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061326 vs ISLR — BRCA

Explore this scatter interactively →