Renal tubule development

Across TCGA cell cohorts, RNA activity of the Renal tubule development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TACSTD2, S100A9, and ALDH3B2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Renal tubule development activity versus TACSTD2 in OVARY (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TACSTD2 →	+6.963	+0.300	<.001	<.001	2	7
URINARY_TRACT	S100A9 →	+4.870	+0.354	.004	.001	3	6
LUNG_NSCLC_LUAD	ALDH3B2 →	+1.385	+0.145	.001	.009	3	6
LUNG_NSCLC_LUAD	MAL2 →	+3.946	+0.196	<.001	.006	3	6
OVARY	FBXO10 →	-0.821	-0.235	.002	<.001	2	6
LUNG_NSCLC_LUAD	TMEM30B →	+2.360	+0.209	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061326 vs TACSTD2 — OVARY

Explore this scatter interactively →