Cardiac neural crest cell development involved in outflow tract morphogenesis

Across TCGA patient cohorts, RNA activity of the Cardiac neural crest cell development involved in outflow tract morphogenesis pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARHGEF17, IGFBP7, and HSPG2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cardiac neural crest cell development involved in outflow tract morphogenesis activity versus ARHGEF17 in UCEC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGEF17 →	+0.339	+0.088	.005	.008	3	9
LSCC	IGFBP7 →	+0.562	+0.120	<.001	<.001	3	9
LSCC	HSPG2 →	+0.469	+0.116	<.001	<.001	3	9
LSCC	SEPTIN2 →	+0.247	+0.149	<.001	<.001	3	8
OV	TNS2 →	+0.313	+0.055	.005	.008	2	9
BRCA	VCL →	+0.365	+0.084	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061309 vs ARHGEF17 — UCEC

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