Cardiac neural crest cell development involved in outflow tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac neural crest cell development involved in outflow tract morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ATP8B3, IKBIP, and CDC42BPG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ATP8B3 grouped by Cardiac neural crest cell development involved in outflow tract morphogenesis-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	ATP8B3 →	+2.008	+1.189	<.001	.001	3	5
LARGE_INTESTINE	IKBIP →	+1.065	+0.997	<.001	<.001	3	5
PANCREAS	CDC42BPG →	-1.337	-1.049	.004	.003	3	4
LIVER	CYP1A1 →	-2.405	-1.359	<.001	.002	3	4
LUNG_NSCLC_LUSC	TBCD →	-0.710	-1.290	.002	<.001	3	4
LUNG_NSCLC_LUSC	RAC3 →	-1.514	-1.178	.008	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ATP8B3 by Cardiac neural crest cell development involved in outflow tract morphogenesis activity — PANCREAS

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