Cardiac neural crest cell development involved in outflow tract morphogenesis

Across TCGA cell cohorts, RNA activity of the Cardiac neural crest cell development involved in outflow tract morphogenesis pathway is significantly associated with the drug response of multiple features, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are PLK_6522, GSK2801, and Topotecan, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLK_6522 grouped by Cardiac neural crest cell development involved in outflow tract morphogenesis-low versus -high activity in OVARY.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PLK_6522 →	-1.616	-0.218	.049	.035	3	1
OVARY	GSK2801 →	+0.680	+0.282	.045	.032	3	1
OVARY	Topotecan →	+1.629	+0.386	.027	.007	3	1
OVARY	Docetaxel →	+2.326	+0.282	.033	.032	3	1
OVARY	741909 →	+1.546	+0.282	.048	.032	3	1
OVARY	743380 →	+1.666	+0.282	.018	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLK_6522 by Cardiac neural crest cell development involved in outflow tract morphogenesis activity — OVARY

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