Retinal blood vessel morphogenesis

Across TCGA patient cohorts, RNA activity of the Retinal blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP1B1, FN1, and COL5A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal blood vessel morphogenesis activity versus CYP1B1 in GBM (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CYP1B1 →	+1.272	+0.161	<.001	<.001	3	7
HNSC	FN1 →	+1.153	+0.214	.006	.001	3	6
OV	COL5A1 →	+1.578	+0.182	.002	.003	3	6
LUAD	LRRC15 →	+1.095	+0.374	.002	.004	2	7
BRCA	COL11A1 →	+1.321	+0.382	.002	.002	3	6
OV	ISLR →	+1.048	+0.189	.007	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061304 vs CYP1B1 — GBM

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