Retinal blood vessel morphogenesis

Across TCGA cell cohorts, RNA activity of the Retinal blood vessel morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC46A3, TFAP4, and ADAMTS12, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC46A3 grouped by Retinal blood vessel morphogenesis-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	SLC46A3 →	-2.040	-1.830	<.001	<.001	3	5
BLOOD_Myeloma	TFAP4 →	+1.530	+1.744	<.001	<.001	2	5
BONE	ADAMTS12 →	-4.145	-1.662	<.001	<.001	3	4
BONE	COL6A3 →	-5.965	-1.737	.004	<.001	3	4
BONE	SH3RF3 →	-2.665	-1.739	<.001	<.001	3	4
BONE	TENM3 →	-3.268	-1.573	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC46A3 by Retinal blood vessel morphogenesis activity — BLOOD_Lymphoma

Explore this box plot interactively →