Cornea development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Cornea development in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ERG_S81, TAP1, and PSMB10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornea development in camera-type eye activity versus ERG_S81 in OV (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ERG_S81 →	-0.779	-0.057	.002	.003	3	6
OV	TAP1 →	-0.528	-0.055	<.001	<.001	3	5
LUAD	PSMB10 →	-0.219	-0.045	.008	.002	3	5
LSCC	AGL →	+0.209	+0.047	<.001	.002	3	5
OV	GBP4 →	-0.527	-0.058	<.001	<.001	3	4
GBM	DLG5 →	+0.228	+0.060	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061303 vs ERG_S81 — OV

Explore this scatter interactively →