Cornea development in camera-type eye

Across TCGA patient cohorts, RNA activity of the Cornea development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LARGE1, H3P36, and ZFP69, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornea development in camera-type eye activity versus LARGE1 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LARGE1 →	+0.925	+0.553	<.001	<.001	3	4
BRCA	H3P36 →	-0.763	-0.449	<.001	.001	3	3
GBM	ZFP69 →	+0.925	+0.234	<.001	<.001	3	3
BRCA	DNM1P46 →	+0.114	+0.454	.002	.003	3	3
BRCA	CKS1BP2 →	-0.898	-0.437	.001	.003	3	3
CCRCC	ALDH1L1 →	-1.041	-0.379	.005	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061303 vs LARGE1 — BRCA

Explore this scatter interactively →