Cornea development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Cornea development in camera-type eye pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLCXD3, KLHL36, and AGXT, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLCXD3 grouped by Cornea development in camera-type eye-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLCXD3 →	+0.117	+1.593	.009	.001	3	4
STOMACH	KLHL36 →	+0.217	+1.108	<.001	.005	3	4
BLOOD_Leukemia	AGXT →	+0.258	+1.207	.001	.001	3	4
LUNG_NSCLC_LUAD	PKN1 →	-0.098	-0.839	.008	.005	3	4
LUNG_SCLC	MED13L →	+0.256	+1.876	.002	<.001	3	3
LUNG_SCLC	CD36 →	+0.163	+1.474	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLCXD3 by Cornea development in camera-type eye activity — LUNG_SCLC

Explore this box plot interactively →