Cornea development in camera-type eye

Across TCGA cell cohorts, RNA activity of the Cornea development in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PAX6, PRICKLE1, and WNT9A, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cornea development in camera-type eye activity versus PAX6 in LIVER (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PAX6 →	+3.739	+1.708	<.001	<.001	3	14
LIVER	PRICKLE1 →	+2.632	+1.292	<.001	.001	2	13
LUNG_NSCLC_LUAD	WNT9A →	+2.169	+1.324	<.001	<.001	3	8
STOMACH	PPFIBP2 →	-2.052	-0.974	.001	.003	3	7
STOMACH	GALNT4 →	-1.516	-1.083	<.001	<.001	3	7
LIVER	AKT3 →	+3.973	+1.441	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061303 vs PAX6 — LIVER

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