Retina vasculature morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Retina vasculature morphogenesis in camera-type eye pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FERMT2, TNS2_S102, and DCN, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina vasculature morphogenesis in camera-type eye activity versus FERMT2 in UCEC (Pearson r = 0.45).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FERMT2 →	+0.607	+0.100	<.001	<.001	3	10
OV	TNS2_S102 →	+1.001	+0.073	<.001	<.001	3	10
BRCA	DCN →	+0.885	+0.066	<.001	<.001	3	10
UCEC	NEXN_S226 →	+0.811	+0.104	.005	.002	3	9
HNSC	TLN2 →	+0.516	+0.114	<.001	<.001	3	9
UCEC	TNS2_S648 →	+0.518	+0.084	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061299 vs FERMT2 — UCEC

Explore this scatter interactively →