Retina vasculature morphogenesis in camera-type eye

Across TCGA patient cohorts, RNA activity of the Retina vasculature morphogenesis in camera-type eye pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GFPT2, FSTL1, and ADGRA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina vasculature morphogenesis in camera-type eye activity versus GFPT2 in OV (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GFPT2 →	+0.794	+0.226	.001	.004	3	6
OV	FSTL1 →	+1.035	+0.277	<.001	<.001	3	6
OV	ADGRA2 →	+0.694	+0.240	.001	.002	3	6
BRCA	SRPX →	+1.429	+0.705	<.001	<.001	3	5
OV	MEDAG →	+1.494	+0.386	<.001	<.001	3	5
OV	GALNT15 →	+0.744	+0.250	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0061299 vs GFPT2 — OV

Explore this scatter interactively →